Table 4.
IRs and IRRs of Treated Depression in Individuals with or without VWD
| Individuals with VWD | Individuals without VWD (Reference) | IRRsa | ||||
|---|---|---|---|---|---|---|
| Treated Depression Cases (PY) | IR per 1000 PY (95% CI) | Treated Depression Cases (PY) | IR per 1000 PY (95% CI) | Crude IRRa (95% CI) | Adjusted IRRa (95% CI) | |
| Overall | 119 (7634) | 15.6 (12.9–18.7) | 846 (72,922) | 11.6 (10.8–12.4) | 1.34 (1.11–1.63) | 1.35 (1.11–1.63)b |
| By sex | ||||||
| Female | 104 (4666) | 22.3 (18.2–27.0) | 695 (43,764) | 15.9 (14.7–17.1) | 1.40 (1.14–1.72) | 1.40 (1.14–1.72)c |
| Male | 15 (2968) | 5.1 (2.8–8.3) | 151 (29,158) | 5.2 (4.4–6.1) | 0.98 (0.57–1.66) | 0.96 (0.56–1.63)c |
| By age group, yearsd | ||||||
| 0–19 | 12 (2862) | 4.2 (2.2–7.3) | 59 (28,326) | 2.1 (1.6–2.7) | 2.01 (1.08–3.74) | 1.98 (1.07–3.69)e |
| 20–39 | 52 (2016) | 25.8 (19.3–33.8) | 408 (20,482) | 19.9 (18.0–22.0) | 1.30 (0.97–1.73) | 1.29 (0.96–1.72)e |
| 40–59 | 47 (1931) | 24.3 (17.9–32.4) | 320 (16,647) | 19.2 (17.2–21.4) | 1.27 (0.93–1.72) | 1.26 (0.47–1.71)e |
| ≥60 | 8 (825) | 9.7 (4.2–19.1) | 59 (7468) | 7.9 (6.0–10.2) | 1.23 (0.59–2.57) | 1.23 (0.59–2.58)e |
| By sex and age group, yearsd | ||||||
| Female | ||||||
| 0–19 | 10 (1412) | 7.1 (3.4–13.0) | 51 (13,698) | 3.7 (2.8–4.9) | 1.90 (0.97–3.75) | – |
| 20–39 | 47 (1313) | 35.8 (26.3–47.6) | 333 (13,168) | 25.3 (22.6–28.2) | 1.42 (1.17–1.92) | – |
| 40–59 | 43 (1399) | 30.7 (22.2–41.4) | 266 (11,908) | 22.3 (19.7–25.2) | 1.38 (1.00–1.90) | – |
| ≥60 | NR (541) | 7.4 (2.0–18.9) | 45 (4989) | 9.0 (6.6–12.1) | 0.82 (0.29–2.28) | – |
| Male | ||||||
| 0–19 | NR (1449) | 1.4 (0.2–5.0) | 8 (14,627) | 0.5 (0.2–1.1) | 2.52 (0.54–11.88) | – |
| 20–39 | 5 (703) | 7.1 (2.3–16.6) | 75 (7314) | 10.3 (8.1–12.9) | 0.69 (0.28–1.72) | – |
| 40–59 | NR (532) | 7.5 (2.0–19.3) | 54 (4738) | 11.4 (8.6–14.9) | 0.66 (0.24–1.82) | – |
| ≥60 | NR (284) | 14.1 (3.8–36.0) | 14 (2479) | 5.6 (3.1–9.5) | 2.49 (0.82–7.57) | – |
Notes: aIRR of treated depression for individuals with VWD compared to those without VWD (reference). bIRR adjusted for sex and age. cIRR adjusted for age. dBased on age at treated depression date. eIRR adjusted for sex.
Abbreviations: CI, confidence interval; IR, incidence rate; IRR, incidence rate ratio; NR, not reportable (counts of 1–5 individuals); PY, person-years; VWD, von Willebrand disease.