Table 4.

Pharmacokinetic Characteristics of Compound 15 and Silibinin

Parameter	15	Silibinin
	iv (2 mg/kg)	iv (2 mg/kg)
Vz (L/kg)	13.271 ± 4.721	2.511 ± 0.180
T1/2 (h)	0.490 ± 0.117	0.153 ± 0.015
Tmax (h)	0.0833	0.0833
Cmax (ng/mL)	373.0 ± 75.4	633.0 ± 19.7
AUC0−∞ (ng/mL·h)	111.0 ± 19.6	175.0 ± 5.0
CL (L·kg−1·h−1)	18.399 ± 2.961	11.428 ± 0.336
MRT0−∞ (h)	0.1830 ± 0.0536	0.1030 ± 0.0156