Table 1.

Assessments for determining complex mTBI domains.

Domain	Positive findings/indication for enrollment
Anxiety/Mood	Global Severity Index (GSI) T-score > 50; or CP-Screen Anxiety(A)/Mood(M) Avg score ≥ 2 or 1+ individual item = 3 BSI-18 subscale T score ≥ 63 (Overall, A, M) Subdomains: Anxiety (A): Mood (M): Both (M/A):
Cognitive	≤7th% on one or more ImPACT composite scores; or CP Screen Cognitive Avg score ≥ 2 or 1+ individual item = 3; AND ≤ 30 on ImPACT Impulse Control; AND < 9 on REY 15
Migraine/ Headache	≥2 on ID Migraine- migraine (M); or ≥ Grade 2 (≥ 50) on HIT-6- headache (HA); or CP-Screen Migraine Avg score ≥ 2 or 1+ individual item = 3 Subdomains: Headache (HA) Only: Both (M/HA): Migraine (M) with ocular/light sensitivity: Migraine (M) with noise sensitivity: Migraine (M) with motion sensitivity:
Ocular	≥2 on smooth pursuits or hor/ver saccades, or near point convergence (NPC) ≥10 cm; or CP-Screen Ocular Avg score ≥ 2 or 1+ individual item = 3
Vestibular	≥2 on vestibulo-ocular reflex (VOR) and/or visual motion sensitivity (VMS); or > 9 total errors on mBESS; or CP-Screen Vestibular Avg score ≥ 2 or 1+ individual item = 3
Sleep	≥5 on PSQI global score, or CP-Screen Sleep Avg score ≥ 2 or 1+ individual item = 3
Autonomic	Increase of 3+ (from resting value) on VAS; or Unable to complete BCBT per patient or clinician

Clinical Profiles Screen (CP-Screen), Brief Symptom Inventory-18 (BSI-18), Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT), REY15-Item Memorization Test (REY 15), Headache Impact Test-6 (HIT-6), Pittsburgh Sleep Quality Index (PSQI), Visual Analogue Scale (VAS), Buffalo Concussion Bike Test (BCBT).