Table 2.

Cases with unresolved disagreements between central and site assessments following independent radiologist review

Participant	Site-assessed progression date	Radiology review (1)	Radiology review (2)	Reason for disagreement	Significance
013	18 Mar 2013	SD at 18 Mar 13*	PD at 5 Mar 13*	Significance of new ascites	Disagreement in interpretation of RECIST
062	4 Sep 2013	SD at 4 Sep 13	PD at 4 Sep 13	Different choice of TLs; subsequent review against site chosen lesions agreed with site	Issue with application of RECIST/choice of target lesions

^*An ad hoc scan was performed on 5 March prior to scheduled assessment on 18 March. This identified new ascites. This was considered a new lesion consistent with PD by one of the radiologists