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. 2023 Jun 14;240(8):1735–1745. doi: 10.1007/s00213-023-06399-3

Table 3.

Reported adverse events by patients

Side effect Mild Moderate Severe Total
Dry mouth 20 5 0 25 (8.3%)
Fatigue 9 10 3 22 (7.3%)
Insomnia 6 7 6 19 (6.3%)
Somnolence 0 14 2 16 (5.3%)
Lethargy 7 8 1 16 (5.3%)
Nausea 11 3 2 16 (5.3%)
Concentration impairment 10 4 1 15 (5.0%)
Headache 9 4 2 15 (5.0%)
Confusion 10 2 1 13 (4.3%)
Dizziness 3 4 3 10 (3.3%)
Cognitive disturbance 5 3 2 10 (3.3%)
Delirium 5 4 0 9 (3.0%)
Decreased weight 9 0 0 9 (3.0%)
Amnesia 5 2 2 9 (3.0%)
Vertigo 4 3 0 7 (2.3%)
Ataxia 4 3 0 7 (2.3%)
Upper abdominal pain 4 2 0 6 (2.0%)
Anorexia 2 2 2 6 (2.0%)
Constipation 4 1 0 5 (1.7%)
Dysgeusia 2 2 1 5 (1.7%)
Anxiety 1 1 3 5 (1.7%)
Tremor 3 2 0 5 (1.7%)
Pharyngitis 0 5 0 5 (1.7%)
Muscular weakness 2 2 1 5 (1.7%)
Vomiting 4 0 1 5 (1.7%)