Table 2.
Descriptives of serum thyroglobulin and urinary iodine concentrations in Tg-Ab negative pregnant women by cohort
| n | Generation R (n = 3548) |
n | INMA (n = 1168) |
|
|---|---|---|---|---|
| Thyroglobulin | 3548 | 1168 | ||
| Gestational week at blood extractiona | 13.2 (12.2–14.9) | 13.4 (12.7–14.3) | ||
| Serum thyroglobulin (Tg), ng/mla | 11.1 (7.0–17.1) | 11.5 (6.9–18.8) | ||
| Elevated Tg ( > 40 ng/ml), n (%)b | 127 (3.6%) | 52 (4.5%) | ||
| Elevated Tg ( > 55 ng/ml), n (%)c | 58 (1.6%) | 24 (2.1%) | ||
| Iodine | 1071 | 1000 | ||
| Gestational week at urine samplinga | 13.1 (12.1–14.6) | 13.4 (12.7–14.3) | ||
| UIC, µg/La | 166 (97–285) | 131 (76–222) | ||
| UI/Creat, µg/ga | 209 (138–307) | 147 (93–246) | ||
| UI/Creat < 150 µg/g, n (%) | 311 (29.0%) | 513 (51.3%) |
Tg thyroglobulin, Tg-Ab thyroglobulin antibody, UI/Creat urinary iodine-to-creatinine ratio, UIC urinary iodine concentration
aData presented as median (25–75th percentiles)
bCut-off value for elevated Tg based on previous studies in adults and school-age children (see “Methods”)
cCut-off value considered elevated from the laboratory where the Tg measurements were performed (i.e., assay manufacturer’s cut-off) (see “Methods”).