Fig. 1.

The experimental timeline. When the mice arrived, they were separated into two cohorts, designated for either the vSD or vITI schedule study. The drug experiments were performed in consecutive balanced Latin square designs with reference measurement taken before and after each experiment. For each mouse, the reference level for a given drug experiment was calculated as the average of the two vehicle reference sessions placed before and after the Latin-square design, respectively. We conducted DOX, YOH, PRO, SCH, and RAC drug studies, where the two latter are presented in a separate article, focussing on dopamine antagonists (Klem et al. 2023). The mice were subsequently pooled and examined in a locomotor activity assay examining all drugs and doses, except for 1.00 mg/kg PRO, as described in the relevant discussion section. Abbreviations: rCPT rodent continuous performance test, vSD variable stimulus duration, vITI variable intertrial interval, DOX doxazosin, YOH yohimbine, PRO propranolol, SCH SCH23390, RAC raclopride, VEH vehicle, DA R dopamine receptor