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. 2023 Jul 3;240(8):1789–1804. doi: 10.1007/s00213-023-06410-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Effects of ACD856 on neurotransmitter release in the hippocampus. Rats were injected with a single dose of ACD856 (10 mg/kg) s.c. and serotonin (5-HT), noradrenaline (NA), dopamine (DA), acetylcholine (ACh) and glutamate (Glu) release were continuously measured by microdialysis. There was a significant increase in the amount of serotonin as measured by a) AUC(0-120 min) values, while a more detailed analysis in b) showed a rapid and transient effect. Noradrenaline and dopamine did not reach significance in AUC (a) but showed significant increases at the 60-90 min timepoint (b). No significant effects of ACD856 on the extracellular levels of acetylcholine or glutamate were seen (data not shown). The statistical analysis was performed using a one-way (Fig. 8a) and two-way repeated measures ANOVA (Fig. 8b) respectively, followed by Bonferroni’s multiple comparison test.