Table 1.
Effect of different doses of diacerein on CHOP immunoreactivity induced by BDL in different experimental groups.
| Group | Sham-operated group | BDL group | BDL + diacerein (10 mg/kg) | BDL + diacerein (30 mg/kg) | BDL + diacerein (50 mg/kg) | Chi square (X2) | p value | p value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | N | % | ||||
| CHOP immune-reactivity | |||||||||||||
| Negative (0) | 8 | 100 | 0 | 0 | 0 | 12.5 | 1 | 25 | 4 | 50 | 26.895 | 0.000** | 0.000** |
| Weak (1) | 0 | 0 | 0 | 0 | 2 | 37.5 | 4 | 50 | 3 | 37.5 | 9.176 | 0.057 | |
| Moderate (2) | 0 | 0 | 3 | 37.5 | 6 | 50 | 3 | 25 | 1 | 12.5 | 12.080 | 0.017 | |
| Strong (3) | 0 | 0 | 5 | 62.5 | 0 | 0 | 0 | 0 | 0 | 0 | 22.857 | 0.000** | |
*Statistically significant difference (p ≤ 0.01), **Statistically highly significant difference (p ≤ 0.001), n: number (number of sacrificed rats in each group = 8 rats), %: Percent. There were statistically significant differences between all groups regarding negative (0) and strong (3) CHOP immunoreactivity.