Table 3.
Effect of different doses of diacerein on fibrotic changes induced by BDL in different experimental groups.
| Group | Sham-operated group | BDL group | BDL + diacerein (10 mg/kg) | BDL + diacerein (30 mg/kg) | BDL + diacerein (50 mg/kg) | Chi square (X2) | p value | p value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | N | % | ||||
| Stage of fibrosis | |||||||||||||
| Stage (0) | 7 | 87.5 | 0 | 0 | 0 | 0 | 1 | 12.5 | 1 | 12.5 | 24.946 | 0.000** | 0.000** |
| Stage (1) | 1 | 12.5 | 0 | 0 | 1 | 12.5 | 3 | 37.5 | 6 | 75 | 14.295 | 0.006* | |
| Stage (2) | 0 | 0 | 1 | 12.5 | 5 | 62.5 | 4 | 50 | 1 | 12.5 | 11.787 | 0.019 | |
| Stage (3) | 0 | 0 | 3 | 37.5 | 2 | 25 | 0 | 0 | 0 | 0 | 9.143 | 0.058 | |
| Stage (4) | 0 | 0 | 4 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 17.778 | 0.001** | |
Comparison of fibrotic stages among different experimental groups *Statistically significant difference (p ≤ 0.01), **Statistically highly significant difference (p ≤ 0.001), n: number (number of sacrificed rats in each group = 8 rats), %: Percent. There are statistically significant differences between all groups regarding all stages of fibrotic changes except stages 2 and 3.