Fig. 1. Genome-wide genetic correlations (r_g) across GWAS traits.

Positive correlations are highlighted in shades of red, whereas negative correlations are highlighted in shades of purple. GWAS sample sizes are presented in Table 1. ** = significant correlations (p-value < 0.0014); * = nominally significant correlations (p < 0.05). AD Alzheimer’s disease, LBD Lewy body dementia, PD Parkinson’s disease, FTD Frontotemporal dementia, ALS Amyotrophic lateral sclerosis, SCZ Schizophrenia, MS Multiple sclerosis, UC Ulcerative colitis, CD Crohn’s disease.