Figure 4.

HMGB protein interactome is enriched with biologically productive RNA binding proteins. APID (Alonso-Lopez et al., 2019; Alonso-Lopez et al., 2016) coupled with a Gene Ontology analysis (Ashburner et al., 2000; Gene Ontology, 2021) identified HMGBs that interact with proteins involved in the following: Molecular Function, binds DNA or RNA; Biological Process, RNA metabolism; and Cellular Component, found within RNP assemblies. A. If at least one HMGB protein interactor had the Gene Ontology assignment it is colored green and if no evidence was found it is colored grey. # of HMGB protein interactors from APID, the % of interactors with DNA or RNA binding assignments, and interactors with or without evidence for each Gene Ontology assignment. B. Total number of HMGBs from A. compiled into pie charts for each Gene Ontology assignment.