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Cartoon of possible mechanisms for how HMGBs impact splicing outcomes by binding RNA. A. HMGBs and splicing factors (SFs) form RNA protein complexes upon nascent RNA, impacting splicing outcomes. B. HMGBs interaction with nascent RNA may block SFs access to RNA or alter splicing complex composition, resulting in altered splicing. C. HMGBs may bind and alter the structure of the RNA to recruit specific SFs or to prevent binding of SFs.
