Table 1.

Summary of literature evidence for HMGB family interactions with RNA. List of HMGBs that directly interact with RNA are labeled as binds. HMGBs that interact with RNA, but it is unknown whether the interaction is direct or indirect are assigned as associates. ^*HMGBs that do not yet have direct RNA binding or association evidence are listed at the bottom. Unknown = UK.

HMGB protein	Binds to RNA, (reference)	Associates with RNA, (reference)
BBX	(Yan et al., 2021)	(Caudron-Herger et al., 2019)
CIC	(Queiroz et al., 2019)	UK
LEF1	(Hamilton et al., 2022)	(B. Li et al., 2021)
Sox1	(Hou et al., 2020)	UK
Sox2	(Hamilton et al., 2022; Holmes et al., 2020), (Cajigas et al., 2021; Hou et al., 2020; Tung et al., 2010)	(Bai et al., 2022; Du et al., 2021; Guo et al., 2018; Jiang et al., 2018; Jing et al., 2020; Q. Li et al., 2021; Ng et al., 2013; Ng et al., 2012; Samudyata et al., 2019; Stamou et al., 2020; Zhang et al., 2020; H. Zhang et al., 2021; Zhou et al., 2022; Zhuang et al., 2015)
Sox4	UK	(Chen et al., 2020)
Sox6	(Hamilton et al., 2022)	UK
Sox9	(Hamilton et al., 2022)	(Girardot et al., 2018; Pei et al., 2021; Penrad-Mobayed et al., 2018)
Sox10	UK	(Stamou et al., 2020)
Sox11	(Hamilton et al., 2022)	UK
Sox13	(Yan et al., 2021)	UK
Sox15	(Hamilton et al., 2022)	UK
Sox17	(Hamilton et al., 2022)	UK
Sox21	(Hamilton et al., 2022)	UK
Sox30	(Hamilton et al., 2022)	UK
SRY	(Hamilton et al., 2022)	UK
TCF7	(Park et al., 2005; Lee & Jeong, 2004)	UK
TFAM	(Castello et al., 2016; Trendel et al., 2019; Baltz et al., 2012; Brown et al., 2015; Castello et al., 2012; Dvir et al., 2021; Lyonnais et al., 2017; Sysoev et al., 2016; Urdaneta et al., 2019; Yan et al., 2021)	(Caudron-Herger et al., 2019)
HM20A	UK	(Mallam et al., 2019)
HM20B	UK	(Caudron-Herger et al., 2019; Mallam et al., 2019)
HMGB1	(Baltz et al., 2012; Beckmann et al., 2015; Bell et al., 2008; Brieno-Enriquez et al., 2019; Castello et al., 2012; Castello et al., 2016; Choi et al., 2020; Dvir et al., 2021; He et al., 2016; Huang et al., 2018; Ignarski et al., 2019; Lee et al., 2012; Oh & Lee, 2014; Queiroz et al., 2019; Sofiadis et al., 2021; Trendel et al., 2019; Yan et al., 2021; Yanai et al., 2009; Yu et al., 2015)	(Gao et al., 2017; Lou et al., 2021; Scherer et al., 2020; Yanai et al., 2011; Yamanaka et al., 2015)
HMGB2	(Baltz et al., 2012; Beckmann et al., 2015; Castello et al., 2012; Castello et al., 2016; He et al., 2016; Iadevaia et al., 2020; Ignarski et al., 2019; Kwon et al., 2013; Queiroz et al., 2019; Trendel et al., 2019; Yamanaka et al., 2015; Yan et al., 2021; Yanai et al., 2009)	(Han et al., 2019; Yamanaka et al., 2015)
HMGB3	(Baltz et al., 2012; Beckmann et al., 2015; Castello et al., 2016; Khoury et al., 2021; Queiroz et al., 2019; Trendel et al., 2019; Yan et al., 2021; Yanai et al., 2009)	UK
HMGXB4	(He et al., 2016; Urdaneta et al., 2019)	UK
MAEL	(Chen et al., 2015; Genzor & Bortvin, 2015)	UK
NSD2	(Sysoev et al., 2016; Yan et al., 2021)	(Caudron-Herger et al., 2019)
PBRM1	(He et al., 2016; Ignarski et al., 2019), (Bao et al., 2018; Urdaneta et al., 2019), (Yan et al., 2021)	(Caudron-Herger et al., 2019)
PMS1	(Castello et al., 2016),	UK
SMARCE1	(He et al., 2016; Urdaneta et al., 2019)	(Caudron-Herger et al., 2019)
SP100	(Queiroz et al., 2019; Yan et al., 2021)	UK
SSRP1	(Baltz et al., 2012; Bao et al., 2018; Beckmann et al., 2015; Castello et al., 2012; He et al., 2016; Huang et al., 2018; Ignarski et al., 2019; Perez-Perri et al., 2018; Queiroz et al., 2019; Urdaneta et al., 2019; Yan et al., 2021)	(Caudron-Herger et al., 2019; Mallam et al., 2019; Wang et al., 2018)
TOX2	UK	(Caudron-Herger et al., 2019)
TOX3	UK	(Caudron-Herger et al., 2019)
TOX4	(He et al., 2016; Urdaneta et al., 2019; Yan et al., 2021)	(Caudron-Herger et al., 2019)
UBTF	(He et al., 2016; Trendel et al., 2019), (Baltz et al., 2012; Ignarski et al., 2019), (Bao et al., 2018; Castello et al., 2012; Perez-Perri et al., 2018; Queiroz et al., 2019; Yan et al., 2021)	(Caudron-Herger et al., 2019; Scherer et al., 2020)
WDHD1	(Bao et al., 2018; Queiroz et al., 2019; Urdaneta et al., 2019; Yan et al., 2021)	UK

^*HMGBs with unknown RNA binding or association experimental evidence: HBP1, Sox3, Sox5, Sox7, Sox8, Sox12, Sox14, Sox18, TCF7L1, TCF7L2, HMGB4, TOX.