Skip to main content
[Preprint]. 2023 Jul 5:2023.07.03.547455. [Version 2] doi: 10.1101/2023.07.03.547455

Figure 6. Inhibitors of Abl signaling reduce DA diameter and cell number in zebrafish embryos.

Figure 6.

(A-E) Dorsal aorta diameter at 28 hpf is reduced in kdrl:GFP embryos treated with 5 μM Dasatinib or 0.5 μM GNF-7 compared to controls treated with 0.1% DMSO.

(F-H) Embryos treated with 5 μM Dasatinib exhibit pericardial edema (arrow) and narrower DA at 4 dpf compared to controls treated with 0.1% DMSO.

(I-K) The number of cells in the DA is reduced in embryos treated with 1 μM GNF-7 compared to control embryos treated with 0.1% DMSO. Error bars show SEM in all graphs. ***p<0.001, ****p<0.0001, Student’s t-test. Data are combined from at least two independent experiments.