Skip to main content
[Preprint]. 2023 Jul 5:2023.07.03.547455. [Version 2] doi: 10.1101/2023.07.03.547455

Figure 7. Inhibition of Abl signaling reverses enlarged DA in she mutant embryos.

Figure 7.

(A-D) she+/−; kdrl:GFP adults were crossed to obtain she mutant embryos. Embryos were treated starting at 6 hpf with either 0.5 μM GNF-7 or 0.1% DMSO. Embryos were imaged at approximately 55 hpf and subsequently genotyped. DA measurements were performed blinded. Mid-trunk region is shown, anterior is to the left. Note the slightly wider DA (red line) in she−/− mutant embryos compared to wild-type (she+/+) siblings. DA is reduced in both wild-type and she mutant embryos treated with GNF-7.

(E) Quantification of DA diameter in wild-type or she mutant embryos treated with GNF-7 or DMSO. Error bars show SEM. **p<0.01, ***p<0.001, NS – not significant, Student’s t-test.

Summary of two independent experiments.