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[Preprint]. 2023 Jul 4:2023.05.25.542131. [Version 2] doi: 10.1101/2023.05.25.542131

Figure 2. Vaccination and IT50 responses in rhesus macaques.

Figure 2.

(Ai) ELISA detection of serum BabA antibodies from vaccinated and adjuvant-only control (Figure S2Ai) rhesus macaques (Table S2A). (Aii) Colony forming units (CFUs)/g of stomach-pinch biopsy tissue, i.e., the infectious loads, were tested at 2, 4, and 8 weeks after the infection and were compared to the control animals (Figure S2Aii) (Table S2B). (B) Test of serum IT50 responses in the vaccinated animals over 2, 4, and 8 weeks with strain 17875 (Europe) and strain I9 (India). The three vaccinated animals no. V2, V3, and V4 responded with de novo IT50s when tested with strain 17875. In contrast, animals no. V1, V5, A2, and A3 demonstrated high pre-challenge titers (Figure S2B). Notably, the I9 Indian strain demonstrated that the three vaccinated animals no. V2, V3, and V4 also responded with bbAb activity. The I9 strain also confirmed the complete lack of de novo IT50s in the non-vaccinated control group (Figure 2B) (Table S2C).