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[Preprint]. 2023 Jul 12:2023.07.07.548119. [Version 3] doi: 10.1101/2023.07.07.548119

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Figure 7. — (A) Western blot validation of AGO2 nuclear localization in CRISPR/Cas9-NLS-AGO2 knock-in HCT116 (NLS-AGO2). (B) Immunofluorescence validation of AGO2 nuclear localization in NLS-AGO2 compared to WT HCT116. (C, D, E) RT-qPCR results describing top candidate miRISC target expression changes in NLS-AGO2 cell line relative to WT (N=3). Significance denoted by *’s with (C) IGF1R, p=0.0004, (D) OLFML2A, p=0.005, (E) NOTCH3, p=0.03.