Table 3. Differentially expressed proteins and phosphoproteins, neurons.
Differentially expressed up and down-regulated proteins and phosphoproteins based on total scores (calculated by multiplying Fold Change by the p-value [−log 2 of 4.32 corresponds to p=0.05]). DEPs shown in descending order.
| Gene | Up-regulated Proteins PPM1D+/tr neurons | Score | Gene | Down-regulated Proteins PPM1D+/tr neurons | Score |
|---|---|---|---|---|---|
| CUL4B | Cullin-4B | 23.32 | PELI2 | E3 ubiquitin-protein ligase pellino homolog 2 | −9.9 |
| SMARCE1 | SWI/SNF-related matrix-associated actin-dependent chromatin regulator | 17.5 | EARS2 | Probable glutamate--tRNA ligase, mitochondrial | −9.97 |
| SLK | STE20-like serine/threonine-protein kinase | 15.6 | NUDT10 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha | −10.02 |
| POFUT1 | GDP-fucose protein O-fucosyltransferase 1 | 14.79 | C3orf49 | Putative uncharacterized protein C3orf49 | −10.07 |
| AUP1 | Lipid droplet-regulating VLDL assembly factor AUP1 | 14.62 | IBA57 | Putative transferase CAF17, mitochondrial | −10.12 |
| DKC1 | H/ACA ribonucleoprotein complex subunit | 13.41 | SLC30A1 | Zinc transporter 1 | −10.17 |
| NEUROG2 | Neurogenin-2 | 12.34 | LACTB | Serine beta-lactamase-like protein LACTB, mitochondrial | −10.72 |
| C5orf22 | UPF0489 | 11.57 | KRT1 | Keratin, type II cytoskeletal 1 | −10.88 |
| SVIL | Supervillin | 11.33 | RAB34 | Ras-related protein Rab-34 | −11.09 |
| PJA2 | E3 ubiquitin-protein ligase | 11.26 | STX4 | Syntaxin-4 | −11.53 |
| TTC28 | Tetratricopeptide repeat protein 28 | 10.5 | UAP1 | UDP-N-acetylhexosamine pyrophosphorylase | −11.61 |
| POLR2C | DNA-directed RNA polymerase II subunit | 10.23 | UPF2 | Regulator of nonsense transcripts 2 | −13.21 |
| PARN | Poly(A)-specific ribonuclease | 10.22 | NCAM2 | Neural cell adhesion molecule 2 | −14.11 |
| NUBP1 | Cytosolic Fe-S cluster assembly factor | 10.11 | TUB | Tubby protein homolog | −16.38 |
| EXOSC6 | Exosome complex component MTR3 | 9.89 | GSTZ1 | Maleylacetoacetate isomerase | −21.19 |
| Gene | Up-regulated phosphoproteins PPM1D+/tr neurons | Score | Gene | Down-regulated phosphoprotein PPM1D+/tr neurons | Score |
| SRRM1 | Serine/arginine repetitive matrix protein 1 | 34.88 | UBR4 | E3 ubiquitin-protein ligase | −30.52 |
| NUCKS1 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 | 33.54 | RIF1 | Telomere-associated protein RIF | −30.80 |
| NUCKS1 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 | 32.75 | CANX | Calnexin | −30.84 |
| MICAL3 | [F-actin]-monooxygenase MICAL3 | 32.61 | NEB | Nebulin | −31.28 |
| NUCKS1 | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 | 31.45 | MADD | MAP kinase-activating death domain protein | −32.21 |
| CWC22 | ubiquitin carboxyl-terminal hydrolase 8 | 30.88 | PLCL1 | Inactive phospholipase C-like protein 1 | −32.30 |
| DCX | Neuronal migration protein doublecortin | 30.56 | SVIL | Supervillin | −33.49 |
| MAP2 | Microtubule-associated protein 2 | 27.14 | DBN1 | Drebrin | −33.63 |
| SCG2 | Secretogranin-2 | 27.12 | ANK2 | Ankyrin-2 | −33.79 |
| RAP1GAP2 | Rap1 GTPase-activating protein 2 | 27.10 | ANK2 | Ankyrin-2 | −34.29 |
| DCX | Neuronal migration protein doublecortin | 26.11 | NAA10 | N-alpha-acetyltransferase 10 | −39.50 |
| AMER2 | APC membrane recruitment protein 2 | 22.99 | ARHGAP35 | Rho GTPase-activating protein 35 | −45.24 |
| CPNE1 | Copine-1 | 22.59 | PRKAR2B | cAMP-dependent protein kinase II-beta regulatory subunit | −46.80 |
| ADCY5 | Adenylate cyclase type 5 | 22.08 | SRSF7 | Serine/arginine-rich splicing factor 7 | −59.87 |
| TRAPPC14 | Trafficking protein particle complex subunit 14 | 21.89 | SRRM1 | Serine/arginine repetitive matrix protein 1 | −68.44 |