Table 4. Gene Ontology (GO) analysis, microglia.

All differentially expressed proteins and phosphoproteins were used to determine GO terms. Only the most significant terms are shown. For the complete list, see Additional file 5: Table S3.

GO term	Microglia Proteomics: Biological Processes	P-value
GO:0035909	aorta morphogenesis	4.74E-05
GO:0072554	blood vessel lumenization	5.37E-05
GO:0048514	blood vessel morphogenesis	8.88E-05
GO:0061314	Notch signaling involved in heart development	1.52E-04
GO:0035912	dorsal aorta morphogenesis	1.52E-04
GO:0009311	oligosaccharide metabolic process	1.59E-04
GO:0044242	cellular lipid catabolic process	2.40E-04
GO:0010885	regulation of cholesterol storage	3.11E-04
GO:0032621	Interleukin 18 production	3.51E-04
GO:0021983	pituitary gland development	4.44E-04
GO:0090136	epithelial cell cell adhesion	4.96E-04
GO:0048844	artery morphogenesis	5.95E-04
GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	5.98E-04
GO term	Microglia Phosphoproteomics: Biological Processes	P-value
GO:0008380	RNA splicing	2.24E-20
GO:0000398	mRNA splicing, via spliceosome	2.80E-19
GO:0051056	regulation of small GTPase mediated signal transduction	5.03E-18
GO:0006397	mRNA processing	1.32E-17
GO:0035556	intracellular signal transduction	1.49E-17
GO:0006338	chromatin remodeling	3.04E-13
GO:0006325	chromatin organization	2.07E-12
GO:0006468	protein phosphorylation	3.39E-11
GO:0007010	cytoskeleton organization	1.19E-10
GO:0006974	cellular response to DNA damage stimulus	2.12E-10