Table 6. Differentially expressed proteins and phosphoproteins, uninduced microglia.
Differentially expressed up and down-regulated proteins and phosphoproteins in baseline, untreated microglia.
| Gene | Up-regulated proteins PPM1D+/tr microglia | Score | Gene | Down-regulated proteins PPM1D+/tr microglia | Score |
|---|---|---|---|---|---|
| CDC34 | Ubiquitin-conjugating enzyme E2 | 29.63 | ACOD1 | Cis-aconitate decarboxylase | −14.10 |
| GBP5 | Guanylate-binding protein 5 | 28.63 | DDX54 | ATP-dependent RNA helicase | −14.14 |
| CD2BP2 | CD2 antigen cytoplasmic tail-binding protein 2 | 26.46 | HERC5 | E3 ISG15--protein ligase | −14.51 |
| KLHDC4 | Kelch domain-containing protein 4 | 26.33 | VPS33A | Vacuolar protein sorting-associated protein 33A | −15.50 |
| SOX3 | Transcription factor SOX-3 | 22.47 | SLC38A2 | Sodium-coupled neutral amino acid transporter 2 | −16.01 |
| PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | 21.52 | MMP13 | Collagenase 3 | −16.11 |
| MAN1B1 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | 21.44 | CDK1 | Cyclin-dependent kinase 1 | −16.67 |
| MYEF2 | Myelin expression factor 2 | 20.04 | GBP1 | Guanylate-binding protein 1 | −16.68 |
| TEP1 | Telomerase protein component 1 | 18.3 | PARP9 | Protein mono-ADP-ribosyltransferase PARP9 | −16.91 |
| CCNK | Cyclin-K | 17.87 | LIMD2 | LIM domain-containing protein 2 | −20.34 |
| DLL4 | Delta-like protein 4 | 17.7 | POGZ | Pogo transposable element with ZNF domain | −28.22 |
| AZI2 | 5-azacytidine-induced protein 2 | 17.28 | SLC38A10 | Putative sodium-coupled neutral amino acid transporter 10 | −30.52 |
| GSTM1 | Glutathione S-transferase Mu 1 | 16.66 | HERC6 | Probable E3 ubiquitin-protein ligase HERC6 | −31.45 |
| DHRSX | Dehydrogenase/reductase SDR family member on chromosome X | 16.03 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | −33.14 |
| ANGEL2 | Protein angel homolog 2 | 14.85 | TANK | TRAF family member-associated NF-kappa-B activator | −46.18 |
| Gene | Up-regulated phosphoproteins PPM1D+/tr microglia | Score | Gene | Down-regulated phosphoproteins PPM1D+/tr icroglia | Score |
| PXN | Paxillin | 14.95 | CLASP2 | CLIP-associating protein 2 | −20.3 |
| DDX54 | ATP-dependent RNA helicase DDX54 | 8.97 | RETREG2 | Reticulophagy regulator 2 | −20.53 |
| TOP2B | DNA topoisomerase 2-beta | 8.85 | MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | −20.92 |
| MACF1 | Microtubule-actin cross-linking factor 1 | 8.21 | TBC1D2BTBC1 | domain family member 2B | −21.38 |
| SRRM1 | Serine/arginine repetitive matrix protein 1 | 8.04 | RASAL3 | RAS protein activator like-3 | −21.7 |
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a2 | 7.9 | AMPD3 | AMP deaminase 3 | −21.94 |
| PARN | Poly(A)-specific ribonuclease PARN | 7.73 | CD2BP2 | CD2 antigen cytoplasmic tail-binding protein 2 | −22.21 |
| CCNY | Cyclin-Y | 7.72 | SNTB1 | Beta-1-syntrophin | −25.43 |
| TRAFD1 | TRAF-type zinc finger domain-containing protein 1 | 7.29 | PI4KB | Phosphatidylinositol 4-kinase beta | −26 |
| TRAFD1 | TRAF-type zinc finger domain-containing protein 1 | 7.08 | SUDS3 | Sin3 histone deacetylase corepressor complex component SDS3 | −26.29 |
| TMEM230 | Transmembrane protein 230 | 6.7 | VPS50 | Syndetin | −29.52 |
| SRRM1 | Serine/arginine repetitive matrix protein 1 | 6.65 | SNX5 | Sorting nexin-5 | −30.13 |
| STX11 | Syntaxin-11 | 6.36 | UFL1 | E3 UFM1-protein ligase 1 | −39.21 |
| ARHGEF2 | Rho guanine nucleotide exchange factor 2 | 6.3 | FLII | Protein flightless-1 homolog | −41.86 |
| DKC1 | H/ACA ribonucleoprotein complex subunit DKC1 | 6.01 | SERF2 | Small EDRK-rich factor 2 | −62.15 |