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[Preprint]. 2023 Jul 7:2023.07.07.548143. [Version 1] doi: 10.1101/2023.07.07.548143

Figure 9: Sea lamprey Aldh1a1/a2a, Cyp26A1, Cyp26B1/C1a respond to drug-induced changes in the levels of RA.

Figure 9:

cISH of (a) Aldh1a1/a2a and (b) Cyp26A1 and Cyp26B1/C1a in DMSO, Talarazole and DEAB treated embryos. For each drug condition, lateral and dorsal views of stage 23 embryos are shown on the top and bottom rows respectively (only heads are a shown). For each gene, 4 embryos were used per treatment condition, and all showed the phenotype shown in the image; (c) cartoon summarizing the gene expression in each treatment condition. Rectangles with dashed lines are used in the DEAB cartoon to represent where the expression of the gene would be expected in WT embryos. fb, forebrain; mb, midbrain; rhombomere (r); (d) Cartoon illustrating mechanisms of self-regulation of the RA machinery where RA downregulates the expression of Aldh1a1/a2a, while up regulating the expression of Cyp26A1, therefore exerting a control on its own synthesis and degradation.