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[Preprint]. 2023 Nov 17:2023.07.06.23292312. Originally published 2023 Jul 8. [Version 2] doi: 10.1101/2023.07.06.23292312

Figure 3. Differential abundance analysis of PGRN mutation carriers versus non-carriers on plasma TMEM106B and GRN protein levels.

Figure 3.

A) Boxplot of the normalized plasma protein TMEM106B levels between PGRN mutation carriers and non-carriers. Mutation carriers have significantly higher TMEM106B levels (p = 0.0151).

B) Boxplot of normalized plasma protein GRN levels between PGRN mutation carriers and non-carriers. Mutation carriers have significantly lower GRN levels (p = 2.89×10−8), Analyses were adjusted for age, sex, and proteomic principal components 1 and 2.