Table 2.

Diagnostic performances in the (a) per-patient and (b) per-lesion analyses

	Expertise	Sensitivity% (95% CI)	Specificity% (95% CI)	NPV% (95% CI)	PPV% (95% CI)	Accuracy% (95% CI)	TP	TN	FP	FN
(a) Per-patient
All patients	Junior radiologist	83.6 (77.5–88.6)	96.6 (94.4–98.1)	92.8 (90.3–94.7)	91.9 (87.0–95.0)	92.5 (90.1–94.5)	158	398	14	31
	Nuclear medicine	81.0 (74.6–86.3)	98.5 (96.9–99.5)	91.9 (89.4–93.8)	96.2 (92.0–98.3)	93.0 (90.7–94.9)	153	406	6	36
	Senior radiologist	89.4 (84.1–93.4)	98.5 (96.9–99.5)	95.3 (93.1–96.9)	96.6 (92.7–98.4)	95.7 (93.7–97.2)	169	406	6	20
Patients referred for initial staging	Junior radiologist	78.3 (66.7–87.3)	98.6 (95.0–99.8)	90.3 (85.6–93.6)	96.4 (87.2–99.3)	91.9 (87.4–95.2)	54	140	2	15
	Nuclear medicine	76.8 (65.1–86.1)	98.6 (95.0–99.8)	89.7 (85.1–93.1)	96.4 (86.9–99.1)	91.5 (86.9–94.9)	53	140	2	16
	Senior radiologist	88.4 (78.4–94.9)	99.3 (96.1–100)	94.6 (90.2–97.1)	98.4 (89.6–99.8)	95.7 (92.1–98.0)	61	141	1	8
Patients referred after biochemical recurrence	Junior radiologist	86.7 (79.3–92.2)	95.6 (92.4–97.7)	94.2 (91.1–96.2)	89.7 (83.2–93.8)	92.8 (89.8–95.2)	104	258	12	16
	Nuclear medicine	83.3 (75.4–89.5)	98.5 (96.3–99.6)	93.0 (89.9–95.2)	96.2 (90.4–98.5)	93.9 (91.0–96.0)	100	266	4	20
	Senior radiologist	90.0 (83.2–94.7)	98.6 (95.7–99.4)	95.7 (92.7–97.4)	95.6 (90.1–98.1)	95.6 (93.1–97.4)	108	265	5	12
(b) Per-lesion
All lesions	Junior radiologist (n = 518)	51.5 (45.7–57.2)	82.1 (76.1–87.2)	52.1 (48.8–55.4)	81.77 (76.5–88.1)	63.5 (59.1–67.7)	157	161	35	148
	Nuclear medicine (n = 427)	48.5 (42.8–54.3)	88.9 (81.0–94.3)	35.9 (33.0–39.0)	93.1 (88.4–96.0)	58.4 (53.4–63.3)	148	88	11	157
	Senior radiologist (n = 454)	63.3 (57.6–68.7)	92.1 (86.0–96.2)	51.1 (47.2–55.0)	95.1 (91.3–97.2)	71.8 (67.3–76.0)	193	117	10	112

CI confidence interval, TP true positive, TN true negative, FP false positive, FN false negative