Table 4.

Diagnostic performance of CT based on the clinical significance (per-patient analysis)

Expertise	Sensitivity% (95% CI)	Specificity% (95% CI)	NPV% (95% CI)	PPV% (95% CI)	Accuracy% (95% CI)	TP	TN	FP	FN
(a) Evaluation based on CHAARTED (Initial staging)
Junior radiologist	63.6 (49.6–76.2)	98.1 (94.5–99.6)	88.4 (84.4–91.6)	92.1 (78.9–97.3)	88.6 (83.6–92.6)	35	153	3	20
Nuclear medicine	60.3 (46.6–73.0)	98.7 (95.3–99.7)	86.8 (82.7–90.0)	94.6 (81.3–98.6)	87.7 (82.5–91.8)	35	151	2	23
Senior radiologist	71.2 (56.9–82.9)	99.4 (96.6–100)	91.3 (87.3–94.2)	97.4 (83.9–99.6)	92.4 (88.0–95.6)	37	158	1	15
(b) Evaluation based on LATITUDE (Initial staging)
Junior radiologist	67.2 (53.7–79.0)	98.7 (95.4–99.8)	88.8 (85.0–92.0)	95.1 (83.0–98.7)	90.1 (85.2–93.7)	39	151	2	19
Nuclear medicine	62.3 (49.0–74.4)	98.7 (95.3–99.8)	86.6 (82.3–89.9)	95 (82.6–98.7)	88.2 (82.3–89.9)	38	148	2	23
Senior radiologist	76.4 (63.0–86.8)	99.4 (96.5–100)	92.3 (88.1–95.0)	97.7 (85.6–99.7)	93.4 (89.1–96.3)	42	155	1	13
(c) Osteo-metastasis evaluation in biochemical recurrent patients
Junior radiologist	72.9 (62.9–81.5)	95.9 (93.0–97.9)	91.6 (88.6–93.8)	85.4 (78.8–91.1)	90.3 (86.9–93.0)	70	282	12	26
Nuclear medicine	70.4 (60.3–79.2)	98.6 (96.5–99.6)	90.9 (88.0–93.1)	94.5 (86.6–97.9)	91.5 (88.3–94.1)	69	288	4	29
Senior radiologist	81.3 (71.8–88.7)	98.3 (96.1–99.5)	94.4 (91.8–96.4)	93.7 (86.1–97.3)	94.4 (91.6–96.4)	74	294	5	17

CI confidence interval, TP true positive, TN true negative, FP, false positive, FN false negative