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. 2023 Jul 3;14:1185570. doi: 10.3389/fimmu.2023.1185570

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Copyright © 2023 Yang, Tong, Wang, Zhao, Ba, Ahelijiang, Liu, Gao, Zhao, Gu, Yang and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Guizhi Fuling capsule (GZFL) represses microglial activation in the hippocampus (HPC) CA1 of presenilin1/2 conditional double knockout (PS cDKO) mice. (A) Representative images of Iba1⁺ microglia in HPC CA1. The location of HPC CA1 was displayed in overview images by the box. Magnification of overview image is 5×, scale bar, 200 μm. Magnification of other four images is 40×, Scale bar, 50 μm. (B) The percentage of amoeboid cells in total Iba1⁺ cells were calculated to conduct a quantitative analysis of microglial activation in HPC CA1. (C–E) The branches (C), the average branch length (D) and longest branch length (E) in HPC CA1. Data are the mean ± SEM (n = 6), *P < 0.05; **P < 0.01.