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. 2023 Jul 11;18(1):20230752. doi: 10.1515/med-2023-0752

Figure 1.

Figure 1

Downregulation of SMOC2 improved cardiac function and damage in HF rats. (a) qPCR and western blot assays showed SMOC2 expression in HF rats. (b) qPCR and western blot assays showed SMOC2 expression in HF rats after SMOC2 knockdown. (c) Echocardiographic parameters of HF rats after SMOC2 knockdown. LVESD: left ventricular end-systolic diameter; LVEDD: left ventricular end-diastolic diameter; EF: left ventricular ejection fraction; FS: left ventricular fractional shortening. (d) and (e) HE and Masson staining showed pathological changes in myocardial tissues of HF rats after SMOC2 knockdown (scale bar = 50 µm). CVF: collagen volume fraction. **P < 0.01 compared to sham group; # P < 0.05 and ## P < 0.01 compared to HF + sh-NC group.