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Downregulation of SMOC2 inhibiting TGF-β1/Smad3 signaling pathway. (a) qPCR showed TGF-β1 and Smad3 expression in HF rats after SMOC2 knockdown. (b) Western blot assay showed TGF-β1, Smad3, and p-Smad3 expression in HF rats after SMOC2 knockdown. **P < 0.01 compared to sham group; ## P < 0.01 compared to HF + sh-NC group.
