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. 2023 Jul 11;18(1):20230752. doi: 10.1515/med-2023-0752

Figure 5.

Figure 5

Downregulation of SMOC2 affected autophagy and mitigated cardiac damage in HF rats via inhibiting the TGF-β1/Smad3 signaling pathway. TGF-β agonist (SRI-011381, 30 mg/kg daily) was intraperitoneally injected into the HF rats that were transfected with sh-SMOC2. (a) qPCR showed SMOC2 expression in rats. (b) and (c) HE and Masson staining showed pathological changes in the myocardial tissues of rats (scale bar = 50 µm). CVF: collagen volume fraction. (d) Western blot assay showed the expression of autophagy- and TGF-β1/Smad3 signaling pathway-related proteins in rats. *P < 0.05 and **P < 0.01 compared to sham group; # P < 0.05 and ## P < 0.01 compared to HF + sh-NC group; & P < 0.05 and && P < 0.01 compared to HF + sh-SMOC2 group.