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. 2023 Jun 14;66(13):9006–9022. doi: 10.1021/acs.jmedchem.3c00633

Figure 1.

Figure 1

Glycopeptide antibiotics. Canonical GPAs like vancomycin and teicoplanin and semisynthetic derivatives such as dalbavancin bind lipid II and inhibit peptidoglycan synthesis. In contrast, Type V GPAs such as complestatin, corbomycin, and rimomycin A bind peptidoglycan and inhibit cell division.