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. 2023 Jun 14;66(13):9006–9022. doi: 10.1021/acs.jmedchem.3c00633

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© 2023 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Deletion of halogenase-encoding rmoL improves rimomycin A production. (A) Chemical structure of rimomycins A, B, and C. (B) Scheme for in-frame deletion of rmoL gene from pGP6783. (C) DNA gel electrophoresis verifies rmoL deletion. Lane i, 1 kb DNA ladder; lane ii, PCR product amplified from rmoL deletion mutant, pGP6783ΔrmoL; lane iii, PCR product amplified from the wild-type plasmid, pGP6783. (D) HPLC chromatograms of rimomycins. Trace i, S. coelicolor M1154/pAMX4/pGP6783; trace ii, S. coelicolor M1154/pAMX4/pGP6783ΔrmoL.