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. 2023 Jun 14;66(13):9006–9022. doi: 10.1021/acs.jmedchem.3c00633

Figure 3.

Figure 3

Compound 17 reduces E. faecium (Van A) dissemination in a mouse neutropenic thigh infection model. (A) Percent weight change in mice infected with E. faecium ATCC 700221 treated with the indicated compounds. (B) Kaplan–Meier survival curve of infected mice treated with the indicated compounds. Mice were considered to have reached endpoint when 15% of their starting weight had been lost (*P < 0.05, Gehan–Breslow–Wilcoxon test). (C) Tissue E. faecium loads at the experimental endpoint. Each data point represents one tissue sample. Individual data points are shown with means and standard deviation. (D) Tissue weight at the experimental endpoint. Each data point represents one tissue sample. Individual data points are shown with means and standard deviation. For (C) and (D), *P < 0.05, ***P < 0.0005, ****P < 0.0001, two-way ANOVA, Tukey test for multiple comparisons.