Table 1. Antimicrobial Activity of Rimomycin A Analogues 1–17 (μg/mL).

compound ID	R1	R2	S. aureus ATCC 33591	M. smegmatis mc2155	VRE-Aa	VRE-Bb	B. subtilis 168
vancomycin	-	-	2	4	>128	32	0.5
rimomycin A	OH	H	8	16	8–16	8–16	2
1	-O-CH2-CH2-OH	-CH2CH2-OH	32	16	32	16	4
2	-O-CH2CH2-SO3H	-CH2CH2-SO3H	>128	>128	>128	>128	32
3	-O-(CH2)6-B(OH)2	-CH2-(CH2)5-B(OH)2	>128	16	64	64	32
4	OH	Boc	16	128	16	8	4
5	-O-(CH2)7CH3	H	>128	>128	>128	32	64
6	-NH-(CH2)3-NH2	H	64	1	1–2	4	4
7	-NH-(CH2)2-NH-CH3	H	64	0.5–1	1–2	4	4
8	-NH-(CH2)3-N(CH3)2	H	>128	0.5	2–4	16	8
9	-NH-(CH2)3-N+(CH3)3	H	>128	0.5	4	16	4
10	-NH-(CH2)3-NH-(CH2)3-N(CH3)2	H	>128	1	2–4	16	8
11	-NH-(CH2)3-N+(CH3)-pyrrolidine	H	>128	1	8	64	32
12	OH	-(CH2)3-CH3	16	>128	32	16	4
13	OH	-(CH2)5-CH3	4	>128	4	4	8
14	OH	-(CH2)7-CH3	8	>128	16	8	32
15	OH	-(CH2)10-CH3	16	>128	16	4–8	128
16	OH	-CO-(CH2)5-NH2	8–16	16	2	4	1
17	-NH-(CH2)3-N(CH3)2	-CO-(CH2)5-NH2	8–16	0.5–1	0.5	1	1

^aEnterococcus faecium ATCC 700221.

^bEnterococcus faecalis ATCC 51299.