Scheme 1. Synthesis of 2.
Reagents and conditions: (a) (3,5-difluorophenyl)boronic acid, Pd(PPh3)4, Na2CO3, 1,4-dioxane/water, 90 °C; (b) HCl, 1,4-dioxane, rt, 84% over two steps; (c) (1-bromoethyl)benzene, KOH, DMF/water, 60 °C, 68%.
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