Table 3. SAR Combination and Lead Optimization on the Indazole-Substituted Pyrimidine-2,4-dione Scaffold.

^aActivity data based on n ≥ 3 with SEM within 0.2 log units, unless otherwise stated.

^bLLE = pIC₅₀ – log D.

^cNCI-H1993 cell lines; activity data based on n ≥ 3 with SEM within 0.2 log units, unless otherwise stated.

^dLog D measured via shake-flask method in octanol and water at pH_7.4.

^en = 2.

^fSEM = 0.22 log units.