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. 2023 Jun 2;14(7):949–954. doi: 10.1021/acsmedchemlett.3c00104

Figure 3.

Figure 3

(a) Compound 1 binds to the central donut cavity of DCAF1 in two orientations. In both crystal structures, the protonated imidazoline moiety makes a hydrogen bond, with the carbonyl of T1097 in pose 1 (PDB ID: 8OG6, cyan) and with the carboxyl moiety of D1356 side chain in pose 2 (PDB ID: 8OG5, green). The hydrogen bonds are shown as dashed black lines. (b) Overlay of crystal structure of 1 bound to DCAF1 (PDB ID: 8OG6, cyan) and to EED (PDB ID: 5H25, orange). The three residues forming the aromatic cages in EED are labeled.