Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 3;4:1202152. doi: 10.3389/fragi.2023.1202152

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Kell, Simon, Alsaleh and Cox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Types of DNA damaging agents, resulting lesions and canonical repair pathways that correct them. DNA experiences a variety of genotoxic insults from both endogenous and exogenous sources. These result in specific lesions that can be repaired via specific DNA repair pathways that are triggered by the DNA damage response (DDR). Damaged DNA is sensed, signalled, and repaired through a cascade of signalling mechanisms elicited by DNA sensors, tranducers, and effectors, which are specific to the DNA lesion type and repair pathway. Examples of such DDR proteins are illustrated. Abbreviations: O6-mG, O-6-methylguanine; 8-oxo-dG, 8-oxo-2′-deoxyguanosine; ICL, interstrand crosslink; HR, homologous recombination; NHEJ, non-homologous end joining; 53BP1, p53·-binding protein 1; MRN complex, Mre11/Rad50/Nbsl; PARP1, Poly [ADP-ribose] Polymerase 1; XP-proteins, Xeroderma Pigmentosum proteins; BRCA1, breast cancer gene 1; MDC1, Mediator of DNA Damage Checkpoint 1; RNF8, Ring Finger Protein 8; ATM, Ataxia-Telangiectasia Mutated; ATR, Ataxia Telangiectasia and Rad3-related; DNA-PK, DNA Protein Kinase complex; Chk1, Checkpoint Kinase 1; Chk2, Checkpoint Kinase 2.