Table 1.
Summary of the characteristics of hypoxia-induced effects on HVA calcium currents and corresponding electrophysiological parameters of RGCs.
| Hypoxia-induced effect on HVA Ca+2 currents | Inhibition | Augmentation | Insensitivity | |||
|---|---|---|---|---|---|---|
| Hypoxia duration | 40–50 s | 60–70 s | 75–85 s | ≥100 s | 40–270 s | 40–270 s |
| Number of cells | n = 7 | n = 7 | n = 7 | n = 9 | n = 4 | n = 4 |
| Level of hypoxia-induced effect | 27 ± 19 | 33 ± 15 | 21 ± 12 | 26 ± 18 | 15 ± 5 | – |
| η | 0.8 ± 0.16 | 0.69 ± 0.2 | 0.24 ± 0.16 | 0.04 ± 0.01 | ||
| n = 7 | n = 5 | n = 4 | n = 5 | |||
| CI99% 0.57–1.02 | CI99% 0.27–1.1 | CI99% −0.22 to 0.71 | CI99% 0.02–0.06 | |||
| ICa, pA | −307 ± 109 | −406 ± 194 | −292 ± 109 | −281 ± 114 | −297 ± 154 | −283 ± 65 |
| Rin, GOm | 0.68 ± 0.32 | 0.77 ± 0.32 | 0.81 ± 0.41 | 0.7 ± 0.28 | 0.84 ± 0.36 | 0.86± 0.37 |
| Cm, pF | 48 ± 13 | 56 ± 12 | 57 ± 13 | 50 ± 12 | 54 ± 12 | 57 ± 13 |
| INa, nA | ~1.5 | ~1.8 | ~1.6 | ~1.7 | ~1.6 | ~1.8 |
| Somata Ø, μm | 23.3 ± 1.7 | 22.3 ± 1.9 | 22.8 ± 2 | 22.6 ± 2.2 | 22.8 ± 2.2 | 23.3 ± 1.7 |
The mean ± SD is given for each parameter. η, recovery index; CI99%, 99% confidence interval for given η; ICa, magnitude of calcium current; Rin, input resistance; Cm, membrane capacity; INa, magnitude of sodium current; Somata , diameter of somata.