SCLC |
Small cell lung cancer |
NSCLC |
Non-small cell lung cancer |
LUAD |
Lung adenocarcinoma |
LSCC |
Lung squamous cell carcinoma |
LLCC |
Lung large cell carcinoma |
CCRT |
Concurrent chemoradiotherapy |
PD-1 |
Programmed death 1 |
PD-L1 |
Programmed death 1 ligand |
CTLA-4 |
Cytotoxic-T-lymphocyte-associated protein 4 |
anti-PD-1 |
Anti-programmed death 1 |
anti-PD-L1 |
Anti-programmed death 1 ligand |
anti-CTLA-4 |
Anti-cytotoxic-T-lymphocyte-associated protein 4 |
FDA |
Food and Drug Administration |
ORR |
Overall response rate |
OS |
Overall survival |
PFS |
Progression-free survival |
EGFR |
Epidermal growth factor receptor |
ALK |
Anaplastic lymphoma kinase |
TMB |
Tumor mutation burden |
mut/Mb |
Mutations/megabase |
IV |
Intravenously |
TMB-H |
TMB-high |
ES-SCLC |
Extensive-stage SCLC |
ICIs |
Immune checkpoint inhibitors |
WES |
Whole exome sequencing |
MMR |
Mismatch repair |
MSI |
Microsatellite instability |
dMMR |
MMR deficiency |
VAF |
Variant allele fraction |
bTMB |
Blood TMB |
ctDNA |
Circulating tumor DNA |
TILs |
Tumor infiltrating lymphocytes |
QIF |
Quantitative immunofluorescence |
SCFAs |
Short chain fatty acids |
TME |
Tumor microenvironment |
CAR-T |
Chimeric antigen receptor T |
NSqNSCLC |
nonsquamous non-small-cell lung cancer |
nab |
nano-particle albumin-bound |
ECOG |
Eastern Cooperative Oncology Group |
TPS |
Tumor Proportion Score |