Comparison of expression levels of (A) PD-1, (B) KLRG1, (C) CTLA-4, and (D) 2B4 on peripheral blood CD8+ T cells of the 83 NPC patients with high or low level of TIM-3/TIGIT co-expression. Comparison of expression levels of (E) PD-1, (F) KLRG1, (G) CTLA-4, and (H) TIGIT on peripheral blood CD8+ T cells of the 83 NPC patients with high or low level of TIM-3/2B4 co-expression (ns, P ≥ 0.05, *P < 0.05, **P < 0.01, ***P < 0.001). PD-1: Programmed cell death protein 1; KLRG1: Killer cell lectin-like receptor subfamily G member 1; CTLA-4: Cytotoxic T-lymphocyte-associated protein 4; NPC: Nasopharyngeal carcinoma; HI: High co-expression; LO: Low co-expression.