Table 2.

Univariate and multiple factor analysis of TIM-3/TIGIT or TIM-3/2B4 co-expression on peripheral CD8+ T cells and overall survival in 83 patients with nasopharyngeal carcinoma

				Multivariate
		Univariate		TIM-3/TIGIT		TIM-3/2B4
Variables		P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)
TIM-3/TIGIT	LO		1		1
	HI	0.011	6.455 (1.839-112.541)	0.028	10.157 (1.286–80.216)
TIM-3/2B4	LO		1				1
	HI	0.04	8.601 (1.101–67.205)			0.129	5.047 (0.625–40.725)
Age (years)	<52		1		1		1
	≥52	0.045	3.816 (1.032–14.115)	0.076	4.035 (0.863–18.874)	0.101	3.670 (0.776–17.361)
Sex	Male		1
	Female	0.776	0.850 (0.277–2.608)
Smoking	No		1		1		1
	Yes	0.012	3.823 (1.343–10.882)	0.093	3.133 (0.825–11.898)	0.082	3.275 (0.861–12.468)
Pathology	NKDC		1
	NKUC	0.474	1.528 (0.478–4.878)
	Other	0.560	1.562 (0.349–6.996)
T stage	T1–2		1
	T3	0.804	0.812 (0.157–4.191)
	T4	0.396	2.086 (0.382–11.397)
N stage	N0–1		1
	N2	0.355	0.469 (0.094–2.333)
	N3	0.665	1.485 (0.248–8.906)
Clinical stage	III		1
	IVA	0.131	2.399 (0.772–7.459)

NKDC: Nonkeratinizing differentiated carcinoma; NKUC: Nonkeratinizing undifferentiated carcinoma; HR: Hazard ratio; CI: Confidence interval. HI: High co-expression; LO: Low co-expression