Table 3.
Univariate and multiple factor analysis of TIM-3/TIGIT or TIM-3/2B4 co-expression on peripheral CD8+ T cells and progression-free survival in 83 patients with nasopharyngeal carcinoma
| Multivariate | |||||
|---|---|---|---|---|---|
| Univariate | TIM-3/TIGIT | ||||
| Variables | P | HR (95% CI) | P | HR (95% CI) | |
| TIM-3/TIGIT | LO | 1 | 1 | ||
| HI | 0.019 | 3.482 (1.226–9.885) | 0.052 | 2.849 (0.990–8.196) | |
| TIM-3/2B4 | LO | 1 | |||
| HI | 0.188 | 2.016 (0.710–5.725) | |||
| Age (years) | <52 | 1 | |||
| ≥52 | 0.776 | 0.850 (0.277–2.608) | |||
| Sex | Male | 1 | |||
| Female | 0.373 | 0.501 (0.110–2.290) | |||
| Smoking | No | 1 | 1 | ||
| Yes | 0.018 | 4.843 (1.306–17.956) | 0.032 | 3.186 (1.104–9.189) | |
| Pathology | NKDC | 1 | |||
| NKUC | 0.318 | 2.206 (0.467–10.42) | |||
| Other | 0.435 | 2.184 (0.307–15.542) | |||
| T stage | T1–2 | 1 | |||
| T3 | 0.789 | 1.193 (0.382–4.335) | |||
| T4 | 0.586 | 1.516 (0.339–6.780) | |||
| N stage | N0–1 | 1 | |||
| N2 | 0.95 | 0.953 (0.211–4.3) | |||
| N3 | 0.374 | 2.161 (0.395–11.827) | |||
| Clinical stage | III | 1 | |||
| IVA | 0.354 | 1.579 (0.600–4.153) | |||
NKDC: Nonkeratinizing differentiated carcinoma; NKUC: Nonkeratinizing undifferentiated carcinoma; HR: Hazard ratio; CI: Confidence interval; HI: High co-expression; LO: Low co-expression.