Table 2.
Association analysis of selected SDC4 SNPs with Metabolic Syndrome
| SNP ID | Position (GRCh38.p14) | Genomic Location | MAF | OR (95% CI)a,b | p-values |
|---|---|---|---|---|---|
| rs2228384-T/C | 45,348,351 | Exon 1 (F-L) | 0.45 | 0.34 (0.15–0.78) R | 0.007 |
| rs2072785-G/T | 45,347,894 | Intron 1 | 0.45 | 0.36 (0.16–0.79) R | 0.007 |
| rs1981429-T/G | 45,347,053 | Intron 1 | 0.40 | 1.83 (1.06–3.14) D | 0.027 |
| rs2267871-A/T | 45,343,730 | Intron 1 | 0.31 | 1.30 (0.63–2.70)R | 0.480 |
| rs2251252-G/A | 45,342,717 | Intron 1 | 0.49 | 0.59 (0.33–1.05)D | 0.071 |
| rs2284277-G/A | 45,338,670 | Intron 1 | 0.22 | 0.87 (0.50–1.51)D | 0.610 |
| rs6130811-C/G | 45,334,849 | Intron 2 | 0.33 | 0.49 (0.17–1.41)R | 0.170 |
| rs2070639-T/G | 45,330,210 | Intron 4 | 0.47 | 1.53 (0.82–2.85)R | 0.180 |
| rs4599-A/G | 45,325,767 | 3’UTR | 0.21 | 0.71 (0.212.42)R | 0.570 |
| rs749111-A/T | 45,322,906 | 3’ near gene | 0.15 | 1.44 (0.81–2.55)D | 0.210 |
| rs11697824-G/A | 45,322,360 | 3’ near gene | 0.17 | 0.74 (0.40–1.34)D | 0.320 |
Abbreviations: MAF: Minor Allele Frequency in our control group; OR: odds ratio; CI: confidence interval
a Logistic regression OR adjusted for age and sex
bFor each SNP the best model was considered: R recessive, D dominant
Significant p-values (< 0.05) are highlighted in bold