Fig. 3.

Therapeutic use of miRNAs in cancer treatment. miRNA replacement therapies or oncogenic miRNA inhibition are the two primary current methods utilized to prevent the overexpression and functions of miRNAs. miRNA replacement therapy such as ligand conjugated miRNAs, liposomes, miRNA mimics, and viral vectors are used to suppress the oncogenic miRNAs. Furthermore, miRNA inhibition therapy includes small molecule inhibitors, miRNA sponge, antisense, and CRISPR/Cas9 which inhibit the oncogenic miRNA’s function. miRNAs microRNAs, CRISPR/Cas9 clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9