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An illustration shows applying Ca12a instead of Cas9 protein, which has the ability to recognize PAM sequences in miRNA editing. By altering the miR-21 coding sequences in glioma cells, CRISPR/Cas12a decreases miR-21 expression through microenvironment cells, which controls both in vitro and in vivo cell proliferation. CRISPR clustered regularly interspaced short palindromic repeats, PAM protospacer adjacent motif, sgRNA single-guide RNA
