Participants with 6-month confirmed ≥20% worsening or improvement on the T25FW (A), SDMT (B), and PASAT (C). As expected, worsening events on the T25FW steadily increase throughout the trial, and worsening events always outnumber improvement events. In contrast, on the SDMT and PASAT, worsening events remain low and stable throughout follow-up, whereas improvement events steadily increase. Improvement events always outnumber worsening events on the SDMT and PASAT.