Table 3.

Summary of effects of biologics on bone biochemical marker in RA

Biologics	Classification	Bone formation marker				Bone resorption marker					Others
		PINP	OC	BAP		CTX	NTX	ICTP	DPD		OPG	RANKL	OPG/RANKL	MMP3	DKK1
Infliximab	TNF-α inhibitor	↑	↑	→		↓	↓	↓	↓		↑	↓	↓
Adalimumab	TNF-α inhibitor	↑				↓							↑
Golimumab	TNF-α inhibitor	↑				↓							↑
Certolizumab	TNF-α inhibitor	↑				↓							↑		↓
Etanercept	TNF-α inhibitor	↑	↑	↑		↓	→				↑→	↓→	↓		↓
Abatacept	CTLA4-Ig										↑	↓			↓
Rituximab	Anti-CD20	↑		↑							↓	↓	↑
Tocilizumab	IL-6 inhibitor	↑				↓					↑		↑	↓	↓