Table 1.

Sensitivity analysis of MR.

Exposure	Outcome	MR Egger pleiotropy test		Heterogeneity test		MR-PRESSO outlier test	MR Steiger directionality test
		Estimate	P value	Q	P value	outlier	Estimated variance explained in exposure	Estimated variance explained in outcome	Correct causal direction
IBD	chickenpox	-0.023	0.267	39.137	0.786	None	1.983	0.117	TRUE
	herpes zoster	-0.003	0.762	48.415	0.416	None	1.983	0.042	TRUE
	mononucleosis	-0.014	0.457	70.443	0.015	None	1.983	0.163	TRUE
UC	chickenpox	-0.047	0.182	36.342	0.134	None	1.354	0.117	TRUE
	herpes zoster	0.004	0.829	27.529	0.490	None	1.354	0.023	TRUE
	mononucleosis	-0.017	0.463	20.897	0.830	None	1.354	0.058	TRUE
CD	chickenpox	-0.004	0.839	30.002	0.875	None	3.555	0.191	TRUE
	herpes zoster	-0.001	0.934	45.84	0.243	None	3.555	0.090	TRUE
	mononucleosis	0.012	0.535	72.017	0.001	None	3.555	0.243	TRUE
chickenpox	IBD	-0.037	0.643	6.704	0.152	None	0.588	0.008	TRUE
	UC	-0.06	0.494	5.314	0.257	None	0.588	0.011	TRUE
	CD	-0.004	0.970	5.524	0.238	None	0.588	0.006	TRUE
herpes zoster	IBD	0.029	0.224	4.958	0.549	None	0.592	0.021	TRUE
	UC	0.046	0.132	7.614	0.268	None	0.592	0.070	TRUE
	CD	0.023	0.465	4.195	0.650	None	0.592	0.064	TRUE
mononucleosis	IBD	-0.026	0.275	6.333	0.706	None	1.265	0.007	TRUE
	UC	-0.057	0.085	6.133	0.727	None	1.265	0.018	TRUE
	CD	0.008	0.794	4.254	0.894	None	1.265	0.010	TRUE