Table 1 |.
Baseline characteristics of participants by latent class membership according to trajectory of depressive symptoms
| Nondepressed (n = 8,630) | Subthreshold depression (n = 7,449) | Persistent depression (n = 1,775) | Emerging depression (n = 1,256) | Total (n = 19,110) | |
|---|---|---|---|---|---|
|
| |||||
| Age (mean (s.d.)) | 75.0 (4.5) | 75.2 (4.6) | 74.9 (4.5) | 75.5 (4.7) | 75.1 (4.5) |
| Gender | |||||
| Male | 3,817 (44.2%) | 3,234 (43.4%) | 731 (41.2%) | 549 (43.7%) | 8,332 (43.6%) |
| Female | 4,813 (55.8%) | 4,215 (56.6%) | 1,044 (58.8%) | 707 (56.3%) | 10,779 (56.4%) |
| Living status | |||||
| At home alone or in a residential home | 2,709 (31.4%) | 2,555 (34.3%) | 708 (39.9%) | 361 (28.7%) | 6,333 (33.1%) |
| At home with someone | 5,921 (68.6%) | 4,894 (65.7%) | 1,067 (60.1%) | 895 (71.3%) | 12.777 (66.9%) |
| Race/ethnicity | |||||
| White/Caucasian | 8,012 (93.9%) | 6,900 (93.5%) | 1,603 (91.2%) | 1,179 (95.2%) | 17,694 (93.6%) |
| Other | 525 (6.1%) | 480 (6.5%) | 154 (8.8%) | 60 (4.8%) | 1,219 (6.4%) |
| Education | |||||
| ≤12 years | 4,761 (55.2%) | 4,318 (58.0%) | 1,106 (62.3%) | 766 (61.0%) | 10,951 (57.3%) |
| >12 years | 3,869 (44.8%) | 3.131 (42.0%) | 668 (37.7%) | 490 (39.0%) | 8,158 (42.7%) |
| Smoking status | |||||
| Current | 281 (3.3%) | 288 (3.9%) | 115 (6.5%) | 50 (4.0%) | 734 (3.8%) |
| Former | 3,311 (38.4%) | 3,198 (42.9%) | 769 (43.3%) | 519 (41.3%) | 7,797 (40.8%) |
| Never | 5,038 (58.4%) | 3,963 (53.2%) | 891 (50.2%) | 687 (54.7%) | 10,579 (55.4%) |
| Alcohol use | |||||
| Current | 6,566 (76.1%) | 5,830 (78.3%) | 1,295 (73.0%) | 947 (75.4%) | 14,638 (76.6%) |
| Former | 456 (5.3%) | 443 (5.9%) | 156 (8.8%) | 81 (6.4%) | 1,136 (5.9%) |
| Never | 1,608 (18.6%) | 1,176 (15.8%) | 324 (18.3%) | 228 (18.2%) | 3,336 (17.5%) |
| Body mass index (kg m−2) | |||||
| ≤25 | 2,291 (26.7%) | 1,944 (26.2%) | 409 (23.2%) | 332 (26.5%) | 4,976 (26.2%) |
| 25–30 | 3,944 (45.9%) | 3,203 (43.2%) | 737 (41.8%) | 555 (44.3%) | 8,439 (44.4%) |
| 30–35 | 1,746 (20.3%) | 1,625 (21.9%) | 424 (24.0%) | 267 (21.3%) | 4,062 (21.4%) |
| >35 | 603 (7%) | 647 (8.7%) | 195 (11.0%) | 99 (7.9%) | 1,544 (8.1%) |
| Quality of life score (measured on SF-12 scale) | |||||
| Physical component (mean (s.d.)) | 50.2 (7.7) | 47.1 (9.1) | 44.6 (10.2) | 48.2 (8.6) | 48.2 (8.8) |
| Mental component (mean (s.d.)) | 58.2 (5.2) | 54.5 (7.0) | 47.8 (9.1) | 56.7 (6.0) | 55.7 (7.1) |
| Number of medical comorbidities | |||||
| 0 | 488 (5.7%) | 337 (4.5%) | 53 (3.0%) | 53 (4.2%) | 931 (4.9%) |
| 1 | 1,919 (22.2%) | 1,379 (18.5%) | 287 (16.2%) | 243 (19.3%) | 3,828 (20.0%) |
| 2 | 2,988 (34.6%) | 2,349 (31.5%) | 527 (29.7%) | 394 (31.4%) | 6,258 (32.7%) |
| 3 | 2,037 (23.6%) | 1,934 (26.0%) | 486 (27.4%) | 329 (26.2%) | 4,786 (25.0%) |
| ≥4 | 1,198 (13.9%) | 1,450 (19.5%) | 422 (23.8%) | 237 (18.9%) | 3,307 (17.3%) |
| Polypharmacy (≥5 medications) | 1,322 (15.3%) | 1,685 (22.6%) | 549 (30.9%) | 285 (22.7%) | 3,841 (20.1%) |
| Antidepressant use | 593 (6.9%) | 932 (12.5%) | 457 (25.7%) | 162 (12.9%) | 2.144 (11.2%) |
| Aspirin arm | 4.345 (50.3%) | 3.767 (50.6%) | 871 (49.1%) | 603 (48.0%) | 9.586 (50.2%) |