Table 3. Multivariable analysis to examine salivary taxa associated with multimorbidity among those with severe periodontal disease (n = 84).
Taxa associated with numbers of diseases and conditions1 of severe periodontitis subjects (n = 84) | ||||
---|---|---|---|---|
Adjusted for caries, gender, age, tobacco use | ||||
Taxa | Coef2 | Std. Dev. | p-value | q-value |
Leptotrichia.s__sp._HMT_221 | −1.1639 | 0.2510 | 0.0000 | 0.0020 |
Tannerella.s__forsythia | −0.9307 | 0.2304 | 0.0001 | 0.0058 |
Desulfobulbus.s__sp._HMT_041 | −1.6614 | 0.4800 | 0.0005 | 0.0279 |
Actinomyces.s__sp._HMT_171 | −1.1273 | 0.3426 | 0.0010 | 0.0407 |
Fusobacterium.s__sp._HMT_203 | −1.6482 | 0.5053 | 0.0011 | 0.0432 |
Streptococcus.s__australis | 0.5120 | 0.1705 | 0.0027 | 0.0685 |
Gemella.s__morbillorum | −0.4752 | 0.1565 | 0.0024 | 0.0685 |
g__Mogibacterium.__ | 0.3913 | 0.1316 | 0.0029 | 0.0730 |
Porphyromonas.s__gingivalis | −0.8105 | 0.2741 | 0.0031 | 0.0738 |
Leptotrichia.s__sp._HMT_212 | −0.5460 | 0.1873 | 0.0035 | 0.0793 |
Capnocytophaga.s__granulosa | −0.6625 | 0.2338 | 0.0046 | 0.0907 |
Fretibacterium.s__fastidiosum | −0.7203 | 0.2558 | 0.0049 | 0.0911 |
Streptococcaceae_.XI..G.4..__ | −1.0637 | 0.3839 | 0.0056 | 0.0958 |
Notes.
Nonredundant diseases and conditions for each subject (Table S1).
Negative coefficient indicates taxa that decrease with high numbers of disease/conditions.
Taxa with differential level of significance at False Discovery Rate of q < 0.1.