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. 2023 Jul 14;11:e15502. doi: 10.7717/peerj.15502

Table 3. Multivariable analysis to examine salivary taxa associated with multimorbidity among those with severe periodontal disease (n = 84).

Taxa associated with numbers of diseases and conditions1 of severe periodontitis subjects (n = 84)
Adjusted for caries, gender, age, tobacco use
Taxa Coef2 Std. Dev. p-value q-value
Leptotrichia.s__sp._HMT_221 −1.1639 0.2510 0.0000 0.0020
Tannerella.s__forsythia −0.9307 0.2304 0.0001 0.0058
Desulfobulbus.s__sp._HMT_041 −1.6614 0.4800 0.0005 0.0279
Actinomyces.s__sp._HMT_171 −1.1273 0.3426 0.0010 0.0407
Fusobacterium.s__sp._HMT_203 −1.6482 0.5053 0.0011 0.0432
Streptococcus.s__australis 0.5120 0.1705 0.0027 0.0685
Gemella.s__morbillorum −0.4752 0.1565 0.0024 0.0685
g__Mogibacterium.__ 0.3913 0.1316 0.0029 0.0730
Porphyromonas.s__gingivalis −0.8105 0.2741 0.0031 0.0738
Leptotrichia.s__sp._HMT_212 −0.5460 0.1873 0.0035 0.0793
Capnocytophaga.s__granulosa −0.6625 0.2338 0.0046 0.0907
Fretibacterium.s__fastidiosum −0.7203 0.2558 0.0049 0.0911
Streptococcaceae_.XI..G.4..__ −1.0637 0.3839 0.0056 0.0958

Notes.

1

Nonredundant diseases and conditions for each subject (Table S1).

2

Negative coefficient indicates taxa that decrease with high numbers of disease/conditions.

3

Taxa with differential level of significance at False Discovery Rate of q < 0.1.